In this talk, the speaker discusses the topic of malware on the Python package index (PyPI) and demonstrates the potential dangers by running malware on their own machine. The speaker explains how malware can be installed from PyPI, how it can be made to look legitimate, and the risks it poses to developers and end users. They also mention some statistics about the costs of data breaches caused by compromised credentials and the prevalence of typosquatting in PyPI packages. The speaker offers advice to both maintainers and users on how to protect themselves from malware and highlights the importance of vetting dependencies and using automated vulnerability scanning tools.